—-今天的封面图是最有名的KEGG新陈代谢路径图,考考大家的眼力,哪一个是三羧酸循环(TCA循环)~~~
现在网上有许多和分子生物学相关的网站,大部分是属于实用型的,BioEngX小编今天推荐的几个网站有的不光实用,而且还十分整洁美观、有趣易用。
KEGG Pathway
全名:KEGG PATHWAY Database
网址:http://www.genome.jp/kegg/pathway.html
一个记录蛋白与蛋白,反应与反应之间联系的数据库网站,基本意思就是,他们记录了现有的各种功能性蛋白质,并且将他们参于的生化反应全部画出来了。就如封面图所示,圆点代表一个特定的酶,而线代表特定的反应,不同系列的反应由不同的颜色表示。每一个圆点和每条线都可以进一步点击,查看这个蛋白或反应的细致内容。
在KEGG的主页我们可以看到,他们不仅仅记录新陈代谢反应,还有其他六个章节的反应路径:
- Metabolism
- Genetic Information Processing
- Environmental Information Processing
- Cellular Processes
- Organismal Systems
- Human Diseases
- Drug Development
今天这篇文章的封面图只是Metabolism这一章节中的第一张路径图(Global View)而已,除此以外还有许多更细致的路径图,所以其内容是相当丰富的。KEGG能给我们提供的是一个全局视野,特别是对搞路径研究、生物催化的童鞋们,这个网站还是很有启发意义的。
Reactome
全名:Reactome: Database of Biomolecular Pathways
网址:http://www.reactome.org/PathwayBrowser/
记录了十九种物种的结构性及功能性生物大分子的关系。与KEGG相比,Reactome除了记录蛋白和催化反应外,更倾向于以整个细胞为单位,记录各种生化功能背后的那些生物大分子的活动,贴一种图来说明:
这是一张人类细胞所有已知生化反应的表现图,在Reactome网站上,这张图是可以随意缩放的,每条线点进去都是详细的路径介绍。除了我们熟知的新陈代谢外,其中更有很多关于细胞分裂、细胞运动、细胞信号的内容。而且每个生化功能背后的蛋白都有详细介绍,除基本功能外,还有蛋白3D晶体结构介绍等等。
GeneMANIA
全名:GeneMANIA
网址:http://genemania.org/
具体为什么是这样一个名字,小编也不知道:(。这是一个极简风格的基因功能预测与联系网站,但是只能在特定物种内进行预测,目前只有九种标准生物,比如E.coli、酵母、果蝇、人类等等。
大概风格就是这样,除了显示出基因与基因之间的联系外,还显示基因的表达情况、与其他基因在基因组中的距离等等信息,更多功能留待各位去看看喽~~
UniProt
全名:UniProt Knowledgebase
网址:http://www.uniprot.org/
搞蛋白的人必去或常去的网站,各种蛋白数据大合集,不得不服!贴张图在这里,就不多说了~~
Size&Scale
全名:Cell Size and Scale
网址:http://learn.genetics.utah.edu/content/cells/scale/
犹他大学的一个网页,小编私以为做的很精致,描述了从cm到pm的尺标大小。
贴图举个栗子
从最大的咖啡豆开始
到常见的X染色体及E.coli
关于科研网站就介绍到这里吧,还有什么实用、简洁又有趣的科研网站,请在文末留言分享给大家哦~
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